Scientific Publications
TGC (Transdermal Glucosamine Cream)

11. The effects of glucosamine derivatives on equine articular cartilage degradation in explant culture.
Fenton JI, Chlebek-Brown KA, Peters TL, et al.
OsteoArthritis and Cartilage. 8:444-451, 2000.

"...Our results indicate that glucosamine sulfate also has the potential to prevent or reduce articular cartilage degradation...."

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12. Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.
Chu SC, Yang SF, Lue -H, et al.
Clinica Chimica Acta. 372:167-172, 2006.
13. Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man.
Persiani S, Roda E, Rovati LC, et al.
Osteoarthritis and Cartilage. 13:1041-1049, 2005.
14. Pharmaceutical and nutraceutical management of canine osteoarthritis: Present and future perspectives.
Henrotin Y, Sanchez C and Balligand M.
The Veterinary Journal. 170:113-123, 2004.
15. Recent advances in glucosamine and chondroitin supplementation.
Owens S, Wagner P and Vangsness CT Jr.
J Knee Surg. 17:185-193, 2004.
16. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.
Bruyere O, Pavelka K, Rovati LC, et al.
Menopause. 11:138-143, 2004.
17. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate.
Christgau S, Henrotin Y, Tanko LB, et al.
Clin Exp Rheumatol. 22:36-42, 2004.
18. Medical management of osteoarthritis of the knee and hip joints.
Grainger R and Cicuttini FM.
Med J Aust. 180:232-236, 2004.
19. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
Richy F, Bruyere O, Ethgen O, et al.
Arch Intern Med. 163:1514-1522, 2003.
20. Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress.
Lippiello L.
Osteoarthritis Cartilage. 11:335-342, 2003.
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